Study record
MILES trial (metformin, short-term mechanistic study in older adults)
Mechanistic/molecular endpoints (e.g. gene-expression/pathway signatures)
Human — Older adults, MILES trial, n=14 Tier 8 · Human acute mechanistic verification: verified
1. Species / populationOlder adults, MILES trial, n=14
2. Exposure, route, scheduleMetformin 1700 mg/day, oral, 6 weeks
3. Comparator & durationPlacebo, 6 weeks
4. Endpoint & numeric resultMechanistic/molecular endpoints assessed; no specific numeric figure supplied in source material
5. What this study did NOT establishNo clinical, functional, or lifespan endpoint; small n, short duration
Full record
| Intervention(s) | Metformin |
| Species | Human |
| Population | Older adults, MILES trial, n=14 |
| Sample size | 14 older adults verification: verified_2026-07-11 |
| Exposure | 1700 mg/day metformin, oral — 6 weeks verification: verified_2026-07-11 |
| Comparator | Placebo |
| Duration | 6 weeks |
| Endpoint | Mechanistic/molecular endpoints (e.g. gene-expression/pathway signatures) |
| Evidence tier | Tier 8 · Human acute mechanistic |
| What was NOT established | Small (n=14), short-duration (6-week) mechanistic study. Does not establish clinical benefit, functional outcome, or lifespan effect. |
Result values (as reported in sourcing brief)
| interpretation | Mechanistic study; sourcing material does not supply a specific quantitative effect-size figure for this dataset |
| verification | verification: verified_2026-07-11 |
Source citation
Verification status: verified This record was checked against its primary publication on 2026-07-11.Identifiers: PMID verified; DOI verified; PMC verified; trial registry ID not reported. Record-level verification and identifier-level status are separate: a record can be fully verified against its primary publication while an identifier that does not apply to the study type — a trial registry ID for an animal study, for instance — is marked not applicable. No identifier is fabricated, and none is left in a “pending” state.
| trial name | MILES |
| pmid | 29383869 verified |
| doi | 10.1111/acel.12723 verified |
| journal | Aging Cell 2018 |
| trial registry id | not reported not reported |
| pmc | PMC5847877 verified |
| authors | Kulkarni AS, Brutsaert EF, Anghel V, et al. (MILES) |
| year | 2018 |
| verified date | 2026-07-11 |
| verified note | n=14 (~70 yo, impaired glucose tolerance), crossover 6 wk metformin/placebo; 647 muscle / 146 adipose genes DE; mTORC1 among upstream regulators. MECHANISTIC, not lifespan/prevention — MATCHES. Resolves earlier 'from task-instruction' flag (n=14, 6 wk confirmed). |
| verification status | verified |
Funding / conflict of interest
not compiled in this proof-of-concept verification: verified_2026-07-11
Version 0.2.0-mvp · literature search date 2026-07-11 · editorial owner Nabus Research