Study record
TAME (Targeting Aging with Metformin) trial -- protocol/registration, no results
Planned aging-related composite clinical endpoint
Human — Adults, TAME trial, planned enrollment greater than 3000 participants Tier 10 · Hypothesis / unreplicated verification: registered trial, no results published
1. Species / populationAdults, TAME trial, planned enrollment >3000
2. Exposure, route, scheduleMetformin, oral, per planned protocol (not yet administered/reported)
3. Comparator & durationPlacebo (planned); trial not yet completed
4. Endpoint & numeric resultNo results available as of 2026-07-11
5. What this study did NOT establishEverything -- this is a registered protocol, not a completed study with results
Full record
| Intervention(s) | Metformin |
| Species | Human |
| Population | Adults, TAME trial, planned enrollment greater than 3000 participants |
| Sample size | >3000 participants (planned) verification: verified_2026-07-11 |
| Exposure | metformin, oral — Per planned trial protocol verification: verified_2026-07-11 |
| Comparator | Placebo (planned) |
| Duration | Trial design; not yet completed as of 2026-07-11 |
| Endpoint | Planned aging-related composite clinical endpoint |
| Evidence tier | Tier 10 · Hypothesis / unreplicated |
| What was NOT established | Nothing yet -- the trial has not reported results. No claim of a metformin longevity effect in humans can be sourced to TAME as of this dataset's literature-search date. |
Result values (as reported in sourcing brief)
| status | PLANNED / REGISTERED -- no results reported as of 2026-07-11 |
| interpretation | No results exist yet; included to make explicit that no completed metformin-lifespan trial result exists |
| verification | verification: verified_2026-07-11 |
Source citation
Verification status: registered trial, no results published This record documents a registered but not-yet-reported trial. There is no results publication, so there is no PMID or DOI to cite — that is a property of the trial's stage, not a gap in this record.Identifiers: PMID not applicable; DOI not applicable; PMC not applicable; trial registry ID not reported. Record-level verification and identifier-level status are separate: a record can be fully verified against its primary publication while an identifier that does not apply to the study type — a trial registry ID for an animal study, for instance — is marked not applicable. No identifier is fabricated, and none is left in a “pending” state.
| trial name | TAME |
| journal | (no results publication) |
| trial registry id | not reported not reported |
| authors | Barzilai N, et al. (AFAR/TAME investigators) |
| registry | ClinicalTrials.gov + AFAR TAME program |
| verified date | 2026-07-11 |
| verified note | As of 2026-07-11: TAME is PLANNED/registry-stage, intended >3000 adults 65-79, composite age-related clinical outcome. NO efficacy results published. Tier 10 (hypothesis/planned). Represent as registered protocol ONLY — no outcome claims. |
| verification status | verified_as_planned |
Funding / conflict of interest
not compiled in this proof-of-concept verification: verified_2026-07-11
Version 0.2.0-mvp · literature search date 2026-07-11 · editorial owner Nabus Research