Human lifespan evidence: none
Classification
Intervention class: Dietary single-amino-acid restriction (isoleucine only, distinct from combined BCAA restriction)
Aliases: Single branched-chain amino acid restriction (isoleucine only)
Relationship to mTOR: Isoleucine is one of three branched-chain amino acids implicated in Sestrin/Rag-mediated mTORC1 activation (see /rag-gtpases). Isolating isoleucine-specific restriction from combined BCAA restriction (/bcaa-restriction) or protein restriction (/protein-restriction) lets this evidence map attribute effects to the correct specific amino acid rather than the whole BCAA class.
Mechanism summary: Isoleucine-specific dietary reduction, studied within the nutritional-geometry research tradition associated with the Solon-Biet/Simpson/Raubenheimer program.
Regulatory status
Dietary intervention; not a drug. No regulatory approval framework applies.
Evidence per species / population (5-qualifier claim format)
Mouse (isoleucine-specific restriction, nutritional-geometry-linked studies) — QUALITATIVE ENTRY (per editorial policy): the sourcing brief lists isoleucine-restriction as a distinct entity from combined BCAA-restriction but does not supply an isoleucine-specific numeric effect size. No number is fabricated here; a human editor must locate the specific isoleucine-restriction primary source before a quantitative claim with a numeric endpoint can be added to this page. Tier 9 · Animal/cell mechanism verification: verified_2026-07-11
1. Species / populationMice, isoleucine-specific dietary restriction studies (nutritional-geometry-linked research program)
2. Exposure, route, scheduleDietary isoleucine specifically reduced (exact ppm/percent reduction is not enumerated in the sourcing brief)
3. Comparator & durationStandard-isoleucine control diet; healthspan/lifespan follow-up
4. Endpoint & numeric resultMetabolic and healthspan changes reported consistent with the broader low-protein/high-carbohydrate geometric-framework findings; the sourcing brief does NOT supply an isoleucine-specific numeric lifespan effect size distinct from the combined-BCAA figure on /bcaa-restriction
5. What this study did NOT establishThis dataset does not have an isoleucine-only numeric lifespan effect size. Did not test humans. No dose-response or sex-specific breakdown is available at the isoleucine-only level in this dataset.
Safety
Safety notes
No established human isoleucine-restriction longevity dose exists. This is a qualitative-evidence page pending a primary source with isoleucine-specific quantitative data.
Source: (not applicable (no drug label; dietary intervention; qualitative page)) verification: verified_2026-07-11
Editorial policy: This site publishes no isoleucine-restriction dosing calculator and no self-directed protocol.
Data model warning: Isoleucine-only restriction (this page), combined BCAA restriction (/bcaa-restriction), and total dietary protein restriction (/protein-restriction) are stored as three SEPARATE intervention entities and must never be conflated.
Funding / conflict of interest
Funding sources and conflict-of-interest disclosures for individual studies are not reproduced here pending primary-source verification; see each linked study record.
Related study records
Version 0.2.0-mvp · literature search date 2026-07-11 · editorial owner Nabus Research